;(21)– [PubMed]; Constantopoulos A, Karpathios T, Nicolaidou P, Maounis F, Matsaniotis N. Lazy-leukocyte syndrome. A case report . The lazy leukocyte syndrome was first described by Miller et al. in in two children with recurrent infection. They had normal humoral and cellular immunity . – LAZY LEUKOCYTE SYNDROME. LAZY LEUKOCYTE SYNDROME. Clinical Synopsis Toggle Dropdown. Inheritance. -? Autosomal dominant new.

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Lazy leukocyte syndrome | definition of lazy leukocyte syndrome by Medical dictionary

A severe neutropenia was found. Bone marrow studies showed normal numbers of mature, morphologically normal neutrophils.

A poor neutrophil response was obtained upon stimulation with both epinephrine and endotoxin, as well as upon induced inflammation by the Rebuck skin window technique. Leukocyte phagocytosis and bactericidal activity were normal. Both random mobility and chemotactic function were defective.

Miller knew of 4 other cases. None is familial and no parental consanguinity is known. Single cases were reported by Costanopoulos et al. The syndrome is distinguished from neutrophil chemotactic deficiencies by the coexistence of defective random motility and peripheral blood neutropenia with normal bone marrow granulocyte reserve.


The same abnormality probably leads to impaired deformability of neutrophils so that release of newly formed neutrophils from the bone marrow is reduced. Relative to the genetics and the possibility that these cases represent new dominant mutations, parental age data would be of interest. Skin window mobilization test and chemotaxis were normal.

A characteristic abnormality of actin distribution in neutrophils was demonstrated. The year-old proposita layz neutropenia and an illness suggestive of persistent Epstein-Barr virus infection.

lazy leukocyte syndrome

Mobilization of leukocytes after exercise was defective. Pathology of chemotaxis and random mobility. A new disorder of neutrophil function. Transient ‘lazy-leukocyte’ syndrome during elukocyte. A bonus to all MIMmatch users is the option to sign up for updates on new gene-phenotype relationships. Clinical Synopsis Toggle Dropdown. Autosomal dominant new mutations.

Lazy leukocyte syndrome.

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